Beyond the Genome and Pharmacogenetics: Precision Medicine

In Pharmacy Success By Dr. Charles Shively / July 18, 2017

Is Precision Medicine for You? Do you wish to foresee your individual health future? The decision to investigate what health challenges .each individual may experience is not for the weak of heart (no pun intended). Most healthcare practitioners embrace the need for interprofessional linkages with fellow professionals (physicians, pharmacists, nurses, nurse practitioners, physician assistants and many others) as they work to provide personalized care for patient/customers. Read more

The Pride. The Passion. The Thrill of Pharmacy.

In Pharmacy Success By Dr. Charles Shively / March 29, 2017

Is this possible? YES. It exists in Aynor, South Carolina…the home of the local high school ”Battling Blue Jackets”. Where is this location that an independent Good Neighbor pharmacy is so successful? Horry County, South Carolina. The Aynor Family Pharmacy was built just four years ago and is positioned at 240 Eighth Avenue (just off SC 501), some thirty miles from North Myrtle Beach, South Carolina and the Atlantic Ocean. Most important: Local patient/customers understand the meaning of “Family” in the Aynor Family Pharmacy name. Read more

Sustainability Toward the Intersection of Pharmacy Technology and Its Future

In Pharmacy Advances By Dr. Charles Shively / February 20, 2017

How Is It We Are? Where were we with pharmacy automation and pharmacy technology ten even five years ago? Can you recall? I do and it is such a success story. As pharmacists, we are ascending a very special path toward sustainability for independent pharmacy profitability. Why? Those independent pharmacies owners who have embraced newer technologies know this. Many large retail chains are even adopting the independent pharmacy learnings. How do we know independent pharmacy is on a special ascension? Read more

Seven Reasons Automated Will-Call Defines Cost-Benefit for Pharmacies

In Pharmacy Success By Dr. Charles Shively / February 10, 2017

Recent independent pharmacy visits have confirmed the value of in-place automated will-call or retrieval systems. This technology, when integrated within the existing pharmacy operational software, pays for itself through the savings in time and various costly error correction events that can occur during everyday pharmacy workflow. From my experience as a pharmacist, I offer the following reasons below. These reasons are based upon use of an Automated Retrieval System (the ARS) offered by RxMedic Systems of Wake Forest, NC. www.rxmedic.com. It is the only automated will-call retrieval system available today which is integrated into existing pharmacy software and is not a separate software add-on to deliver medications at point of sale. Read more

The Epigenetic Clock and Longevity

In Healthcare Advances By Dr. Charles Shively / February 10, 2017

Many alterations occur to our genome or DNA as we age. Some of these changes are epigenetic modifications to our DNA without altering the genetic sequence itself. The human genome is the complete assembly of DNA (deoxyribonucleic acid) that makes each individual unique. The genome consists of about 3 billion base pairs...half from the mother and half from the father. DNA holds the instructions for building the proteins that carry out a variety of functions in a cell. Chemical compounds and proteins that can attach to DNA comprise what is known as the epigenome. These epigenomic compounds attach to DNA as "tags" and change the way individual cells use the DNA's instructions. Importantly these tags or "marks"... as they are known... do not change the sequence of the DNA but rather how the cells operate. Read more

Personalized Therapeutics through Pharmacogenomics

In Patient Engagement By Dr. Charles Shively / February 8, 2017

Introduction Most healthcare professionals are aware of the emerging field of pharmacogenomics. Many are not aware however that it is nearing its 15th year of pursuit to combine the science of how drugs work (pharmacology) with the science of the human genome (genomics). Although the field of pharmacogenomics is still in its infancy with only limited use in select disease areas such as cancer, cardiovascular challenges, HIV, Alzheimer’s and asthma, the coordination between United States research centers is accelerating the pace and implementation in several new disease states. This approach to personalized medicine is a significant departure from previous drug development where the idea has existed that each drug works pretty much the same in every individual and where by exception over time is has been learned that many different aspects must be considered when a medication is provided to the end user. Read more

Considerations at The Intersection of Cognitive Ageing and Psychobiology

In Healthcare Advances By Dr. Charles Shively / February 8, 2017

Cognitive decline is a normal consequence of the age-related changes in the physiology of the brain and the larger senescence every human being experiences. Cognitive decline is often presumed, by the unknowing, to be a precursor to dementia. It is not. Dementia is not a part of normal aging. It represents a group of symptoms caused by disorders that affect the ability to think so severely that it impairs one's ability to perform normal activities like eating or getting dressed. Memory loss is a common symptom of dementia, but memory loss by itself does not mean that someone has dementia. Age-related memory loss as part of cognitive decline manifests itself as the rare occasion, for example, of making a bad decision, missing a monthly payment, forgetting which day it is and remembering later, sometimes forgetting which word to use or losing things from time to time. Read more

Nutritional Influence on Cognitive Decline

In Healthcare Advances By Dr. Charles Shively / February 8, 2017

The First Stage of Cognitive Decline Cognitive decline is associated with various neurodegenerative diseases which are caused by changes in the brain possessing neurotransmission decay. These neurodegenerative diseases can include mild cognitive impairment (MCI), Memory Loss, Alzheimer’s disease, other Dementias and in certain cases Parkinson’s Disease. Read more

Why We Get Hungry and Cannot Lose Weight

In Healthcare Advances By Dr. Charles Shively / February 6, 2017

Perhaps surprising is that an individual’s weight actually triggers why we get hungry. Hunger “pangs” causes the forced interplay of two hormones: leptin and ghrelin and the subsequent influence of another hormone (insulin) produced by the pancreas. How then does this happen? Read more