Bioactive Peptides as Pharmacologic Agents for Metabolic Syndrome

In Healthcare Advances By Dr. Charles Shively / November 27, 2017

By definition a bioactive compound is a compound that has an effect on a living organism or tissue/cell. One large category of bioactive compounds are bioactive peptides. Organic in nature, they are formed by amino acids which join together through covalent bonds (amide or peptide bonds). These bioactive peptides are encrypted in the structure of parent proteins and can be released in-vitro and in-vivo as active secondary metabolites through cleavage of the larger prepropeptides.. Once active, these peptides may act as regulatory compounds with hormone or drug like activity. They eventually modulate various physiological functions through binding interactions to specific receptors on target cells leading to inducement of the physiological response. Read more

The Epigenetic Clock and Longevity

In Healthcare Advances By Dr. Charles Shively / February 10, 2017

Many alterations occur to our genome or DNA as we age. Some of these changes are epigenetic modifications to our DNA without altering the genetic sequence itself. The human genome is the complete assembly of DNA (deoxyribonucleic acid) that makes each individual unique. The genome consists of about 3 billion base pairs...half from the mother and half from the father. DNA holds the instructions for building the proteins that carry out a variety of functions in a cell. Chemical compounds and proteins that can attach to DNA comprise what is known as the epigenome. These epigenomic compounds attach to DNA as "tags" and change the way individual cells use the DNA's instructions. Importantly these tags or "marks"... as they are known... do not change the sequence of the DNA but rather how the cells operate. Read more

Considerations at The Intersection of Cognitive Ageing and Psychobiology

In Healthcare Advances By Dr. Charles Shively / February 8, 2017

Cognitive decline is a normal consequence of the age-related changes in the physiology of the brain and the larger senescence every human being experiences. Cognitive decline is often presumed, by the unknowing, to be a precursor to dementia. It is not. Dementia is not a part of normal aging. It represents a group of symptoms caused by disorders that affect the ability to think so severely that it impairs one's ability to perform normal activities like eating or getting dressed. Memory loss is a common symptom of dementia, but memory loss by itself does not mean that someone has dementia. Age-related memory loss as part of cognitive decline manifests itself as the rare occasion, for example, of making a bad decision, missing a monthly payment, forgetting which day it is and remembering later, sometimes forgetting which word to use or losing things from time to time. Read more

Nutritional Influence on Cognitive Decline

In Healthcare Advances By Dr. Charles Shively / February 8, 2017

The First Stage of Cognitive Decline Cognitive decline is associated with various neurodegenerative diseases which are caused by changes in the brain possessing neurotransmission decay. These neurodegenerative diseases can include mild cognitive impairment (MCI), Memory Loss, Alzheimer’s disease, other Dementias and in certain cases Parkinson’s Disease. Read more

Why We Get Hungry and Cannot Lose Weight

In Healthcare Advances By Dr. Charles Shively / February 6, 2017

Perhaps surprising is that an individual’s weight actually triggers why we get hungry. Hunger “pangs” causes the forced interplay of two hormones: leptin and ghrelin and the subsequent influence of another hormone (insulin) produced by the pancreas. How then does this happen? Read more

The Health Power of Raw Honey

In Healthcare Advances By Dr. Charles Shively / February 6, 2017

Many individuals are unaware that raw honey is a powerhouse of health benefits. Everyone realizes it is a sweetener but how about honey’s enzyme-rich, vitamin and mineral containing, anti-microbial, antioxidant and antibiotic capabilities? Surprised? Read more

The Conundrum of Food Addiction and Weight Loss

In Healthcare Advances By Dr. Charles Shively / February 6, 2017

Would you agree food addiction and weight loss can be a complex and difficult problem to manage? Where can food addiction and weight loss meet to ensure desired success? Read more

Senescence and Nutrition

In Healthcare Advances By Dr. Charles Shively / January 13, 2017

Dehabilitation or Regeneration? If one visits various dictionaries, the definition of senescence typically includes reference to the process of aging and the degenerative loss of various body functions or processes. In brief,”one who begins to age”. Age-related loss of function is a trait of virtually all organisms that age. In humans, age-related degeneration gives rise to a host of well-recognized challenges: atherosclerosis and heart failure, osteoporosis, macular degeneration, pulmonary insufficiency, renal failure, neurodegeneration (for example Alzheimer’s and Parkinson’s diseases) and various others. These changes begin to show them typically mid-life beginning in the 50-60 years of age range. From a pathological standpoint it is typically about debilitating losses of tissue or cellular function.  Read more