Evidence-Based Clinical Trial Design for Weight Loss with Dietary Supplements

In Healthcare Advances By Dr. Charles Shively / August 13, 2018

Abstract: During the past fifteen years the evolution of clinical trial activities for weight loss associated with dietary supplement use has expanded and become more definitive. Previous clinical trials often used extensive and intricate analysis of the effects of apparent metabolic disorder as impacted by different meal replacement adjustments through available and readily assessable variables or endpoints. Today the clinical trials being conducted include controlled environment conditions for the study participants with data collection involving various specific metabolic variables and the impact of individual microbiome on metabolism and metabolic syndrome control. Ten landmark studies are reviewed to showcase the emergence of evidence-based clinical trial design and resultant outcomes. Discussion: Which comes first? Weight loss or glucometabolic regulation? Glucometabolic regulation is the catalyst which can adjust or impart alterations in the Read more

Global Research Defines Dietary Supplements Today

In Healthcare Advances By Dr. Charles Shively / August 13, 2018

What is Quality? Quality in a dietary supplement is the essence of commitment by a manufacturer to ensuring consumer satisfaction with product use. How is quality ensured? It starts with meticulous attention to the selection and testing of raw materials used in the product and subsequent production techniques. Special conditions during production must be monitored and include final quality testing to meet the established specifications for ingredient content of all ingredients in the finished product is mandatory. What remains to be completed? The answer is clinical research….worldwide…through advanced clinical models in those countries where the product is sold. Do consumers care about these studies? Market research says YES! Read more

Inflammation: Long Term Solutions for Life

In Healthcare Advances By Dr. Charles Shively / April 17, 2018

The relationship between inflammation in the body and metabolic disorder (diabetes, insulin resistance, obesity, dyslipidemia and hypertension) is complex. This is in contrast to how a healthy body uses the immune system to trigger an inflammatory response (cascade) to take care of injury. In this response the immune system sends white blood cells to take care of the damage to begin the healing process. When injuries or infections occur this series of events signifies a healthy immune system response.What can interfere with this immune system response? Damaging inflammation to this healthy response occurs when an area of the body remains swollen and does not let the healing process begin. In most cases, chronic inflammation short circuits this healthy response. Read more

Bioactive Peptides as Pharmacologic Agents for Metabolic Syndrome

In Healthcare Advances By Dr. Charles Shively / November 27, 2017

By definition a bioactive compound is a compound that has an effect on a living organism or tissue/cell. One large category of bioactive compounds are bioactive peptides. Organic in nature, they are formed by amino acids which join together through covalent bonds (amide or peptide bonds). These bioactive peptides are encrypted in the structure of parent proteins and can be released in-vitro and in-vivo as active secondary metabolites through cleavage of the larger prepropeptides.. Once active, these peptides may act as regulatory compounds with hormone or drug like activity. They eventually modulate various physiological functions through binding interactions to specific receptors on target cells leading to inducement of the physiological response. Read more

Come Along If You Dare

In Patient Engagement By Dr. Charles Shively / November 27, 2017

When did you last journey to the center of your mind? Ever? Never? In today’s healthcare environment, the use of psychedelic drugs is helping patient individuals (through clinical involvement) to relieve themselves of various challenges: depression, addiction (alcoholism, heroin, cocaine, smoking), schizophrenia and anxiety in terminal cancer patients. Is this true? YES! Read more

America's Pharmacy Tour Collaboration

In Pharmacy Advances By Dr. Charles Shively / October 23, 2017

Which comes first? Technology or Automation or Sustainability or Profitability. Read more

Commentary on Alternative Therapies and Life Style Interventions for Obese Individuals with Type 2 Diabetes

In Patient Engagement By Dr. Charles Shively / September 18, 2017

With obesity worldwide reaching pandemic levels (recent global research indicates over 2 billion individuals are either obese or overweight…one-third of the world population), it has pervaded countries with greatly different cultures and nutritional habits. Many different interventions have been offered and researched in the past ten years, with some intervention approaches being significantly better than others. As practitioners look for alternative therapies for patients who are obese with Type 2 Diabetes and view best practice approaches available, the current controversy using the traditional Metformin and GLP 1 Receptor Agonists (Byetta, Bydureon, Tanzaum, Trulicity and Victoza) has caused many practitioners to consider alternative therapies. Additionally, in the US alone, one-third of the 323 milllion population (2016) is classified as diabetic or pre-diabetic by the CDC (US Centers for Disease Control and Prevention). Read more

Points of Difference Define Pharmacy Technology Today

In Pharmacy Advances By Dr. Charles Shively / August 29, 2017

How Is It We Are? Which comes first? Technology and automation or sustainability and profitability? In today’s independent pharmacy environment many of the needs for sustainability and profitability has caused an influx of new automated technologies that emphasize labor reduction, improved workflow efficiencies and error avoidance. Automated technology designers and equipment manufacturers have been brought to the independent pharmacy marketplace by these needs. Read more

Beyond the Genome and Pharmacogenetics: Precision Medicine

In Pharmacy Success By Dr. Charles Shively / July 18, 2017

Is Precision Medicine for You? Do you wish to foresee your individual health future? The decision to investigate what health challenges .each individual may experience is not for the weak of heart (no pun intended). Most healthcare practitioners embrace the need for interprofessional linkages with fellow professionals (physicians, pharmacists, nurses, nurse practitioners, physician assistants and many others) as they work to provide personalized care for patient/customers. Read more

The Pride. The Passion. The Thrill of Pharmacy.

In Pharmacy Success By Dr. Charles Shively / March 29, 2017

Is this possible? YES. It exists in Aynor, South Carolina…the home of the local high school ”Battling Blue Jackets”. Where is this location that an independent Good Neighbor pharmacy is so successful? Horry County, South Carolina. The Aynor Family Pharmacy was built just four years ago and is positioned at 240 Eighth Avenue (just off SC 501), some thirty miles from North Myrtle Beach, South Carolina and the Atlantic Ocean. Most important: Local patient/customers understand the meaning of “Family” in the Aynor Family Pharmacy name. Read more