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Ageing and DNA Demise

Category: Healthcare Advances Written by Dr. Charles Shively / August 11, 2022

Advances in genomic medicine demonstrate that many diseases are caused by disturbances at the DNA level. Our health destiny is intricately linked to how our genes behave in response to our environments and lifestyles. Which DNA form is most responsible for ageing? B-Form Minor Groove or Major Groove? A-Form Nucleic Acid? Z-Form DNA? Most individuals who are not molecular biologists are not aware that our DNA can occur in three primary configurations. Each of these configurations, located within the control center or nucleus of each cell of our body, can experience damage through errors to its ongoing structure sequence reproduction. B-Form and A-Form DNA are versions of the double helix linear strand structure. Z-Form has an irregular structure not based on the double helix linear strand of B-Form and A-Form DNA. Read more ...

Inexpensive Delivery of Necessary Biologically-Active Peptides and Amino Acids

Category: Healthcare Advances Written by Dr. Charles Shively / August 11, 2022

Abstract: The human digestive system, when presented with easily-converted OTC (over-the-counter) digestive formulas can be perhaps be the most effective delivery system available for essential key elements that control our metabolism and many physical and mental health balances. Dietary supplement formulations are often overlooked yet they are the most inexpensive delivery method for bringing these key essential elements to our health. Discussion: An excellent example of this process is the delivery of the powerful bioactive peptide lunasin. Lunasin is a very small structured compound and an extremely bioactive contributor for health. It works at the most basic human level and actually directs how our existing DNA or genetic code influences the body. Lunasin is a naturally occurring, biologically active, peptide. Peptides are the building blocks of proteins and are composed of naturally occurring amino acids.  Lunasin contains 43 amino acids. Considering the fact that the human body is composed of nearly 30 trillion individual cells, lunasin presence, taken into the body through oral ingestion, can be and is a prime-time player in human health. Read more ...

Evidence-Based Clinical Trial Design for Weight Loss with Dietary Supplements

Category: Healthcare Advances Written by Dr. Charles Shively / August 11, 2022

Abstract: During the past fifteen years the evolution of clinical trial activities for weight loss associated with dietary supplement use has expanded and become more definitive. Previous clinical trials often used extensive and intricate analysis of the effects of apparent metabolic disorder as impacted by different meal replacement adjustments through available and readily assessable variables or endpoints. Today the clinical trials being conducted include controlled environment conditions for the study participants with data collection involving various specific metabolic variables and the impact of individual microbiome on metabolism and metabolic syndrome control. Ten landmark studies are reviewed to showcase the emergence of evidence-based clinical trial design and resultant outcomes. Discussion: Which comes first? Weight loss or glucometabolic regulation? Glucometabolic regulation is the catalyst which can adjust or impart alterations in the Read more ...

Global Research Defines Dietary Supplements Today

Category: Healthcare Advances Written by Dr. Charles Shively / August 11, 2022

What is Quality? Quality in a dietary supplement is the essence of commitment by a manufacturer to ensuring consumer satisfaction with product use. How is quality ensured? It starts with meticulous attention to the selection and testing of raw materials used in the product and subsequent production techniques. Special conditions during production must be monitored and include final quality testing to meet the established specifications for ingredient content of all ingredients in the finished product is mandatory. What remains to be completed? The answer is clinical research….worldwide…through advanced clinical models in those countries where the product is sold. Do consumers care about these studies? Market research says YES! Read more ...

Inflammation: Long Term Solutions for Life

Category: Healthcare Advances Written by Dr. Charles Shively / August 11, 2022

The relationship between inflammation in the body and metabolic disorder (diabetes, insulin resistance, obesity, dyslipidemia and hypertension) is complex. This is in contrast to how a healthy body uses the immune system to trigger an inflammatory response (cascade) to take care of injury. In this response the immune system sends white blood cells to take care of the damage to begin the healing process. When injuries or infections occur this series of events signifies a healthy immune system response.What can interfere with this immune system response? Damaging inflammation to this healthy response occurs when an area of the body remains swollen and does not let the healing process begin. In most cases, chronic inflammation short circuits this healthy response. Read more ...

Bioactive Peptides as Pharmacologic Agents for Metabolic Syndrome

Category: Healthcare Advances Written by Dr. Charles Shively / August 11, 2022

By definition a bioactive compound is a compound that has an effect on a living organism or tissue/cell. One large category of bioactive compounds are bioactive peptides. Organic in nature, they are formed by amino acids which join together through covalent bonds (amide or peptide bonds). These bioactive peptides are encrypted in the structure of parent proteins and can be released in-vitro and in-vivo as active secondary metabolites through cleavage of the larger prepropeptides.. Once active, these peptides may act as regulatory compounds with hormone or drug like activity. They eventually modulate various physiological functions through binding interactions to specific receptors on target cells leading to inducement of the physiological response. Read more ...

Come Along If You Dare

Category: Patient Engagement Written by Dr. Charles Shively / August 11, 2022

When did you last journey to the center of your mind? Ever? Never? In today’s healthcare environment, the use of psychedelic drugs is helping patient individuals (through clinical involvement) to relieve themselves of various challenges: depression, addiction (alcoholism, heroin, cocaine, smoking), schizophrenia and anxiety in terminal cancer patients. Is this true? YES! Read more ...

America's Pharmacy Tour Collaboration

Category: Pharmacy Advances Written by Dr. Charles Shively / August 11, 2022

Which comes first? Technology or Automation or Sustainability or Profitability. Read more ...

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Category: Main Content Written by Dr. Charles Shively / August 11, 2022


Commentary on Alternative Therapies and Life Style Interventions for Obese Individuals with Type 2 Diabetes

Category: Patient Engagement Written by Dr. Charles Shively / August 11, 2022

With obesity worldwide reaching pandemic levels (recent global research indicates over 2 billion individuals are either obese or overweight…one-third of the world population), it has pervaded countries with greatly different cultures and nutritional habits. Many different interventions have been offered and researched in the past ten years, with some intervention approaches being significantly better than others. As practitioners look for alternative therapies for patients who are obese with Type 2 Diabetes and view best practice approaches available, the current controversy using the traditional Metformin and GLP 1 Receptor Agonists (Byetta, Bydureon, Tanzaum, Trulicity and Victoza) has caused many practitioners to consider alternative therapies. Additionally, in the US alone, one-third of the 323 milllion population (2016) is classified as diabetic or pre-diabetic by the CDC (US Centers for Disease Control and Prevention). Read more ...